He was the first Vice President of the United States to resign the office.
- Andrew Johnson
- John C. Calhoun
- John Tyler
- Spiro Agnew
He was the first Vice President of the United States to resign the office.
John C. Calhoun. Calhoun was Andrew Jackson vice-president and had many conflicts with the president over trade and tariff policies. He resigned to become a senator from South Carolina.