This was the most common cause of death from disease among emigrants along the Oregon Trail.
Cholera
Typhus
Indian attack
Starvation
Cholera. Of the estimated 350,000 people who traveled the Oregon Trail about 1 in 17 died along the way, or just over 20,000 people. The most common cause of death or injury, according to the research done by Peter D. Olch, was not a disease – it was being run over by wagon wheels.