French explorer Jacques Cartier sets sail for North America.
Anne Boleyn, Henry VIII's second wife, is beheaded on Tower Green.
Defeated by the Protestants, Mary, Queen of Scots, flees to England where Queen Elizabeth imprisons her.
Cardinal Richelieu of France intervenes in the great conflict in Europe by declaring war on the Hapsburgs in Spain.
Senator Charles Sumner speaks out against slavery.
A pro-slavery band led by Charles Hamilton executes unarmed Free State men near Marais des Cygnes on the Kansas-Missouri border.